M-2000's ability to transport trailer trucks as well as passengers on the same guideway is the key to making maglev a low cost, nationwide mode of transport in the United States. The US currently spends over more than 260 billion dollars annually on intercity truck transport, over 4 times as much as it spends on intercity air passenger transport. Using the M-2000 system, a tractor from the trucking company would pick up a trailer at its origin point and drive it to the nearest maglev station. From there, the trailer would be transported hundreds of miles on a M-2000 maglev vehicle to the station nearest its destination, where it would be picked up by a second tractor and delivered to the destination (see Intercity Trucks). The trailer transport vehicle could also carry freight containers, if desired.

The revenues from transporting 2000 trailers per day - a small fraction of the daily truck traffic on many of the US Interstates - are equivalent to carrying 100,000 passengers per day, which far exceeds any intercity traffic load in the United States. By carrying trailer trucks the payback time for an M-2000 intercity maglev system can be cut to as little as 3 years, compared to the 30 or more years it would take if the system only carried passengers.

Maglev2000 is planning a 20 mile Maglev route in central Florida that would connect Port Canaveral to the regional airport in Titusville, with an intermediate station at the Visitor Center in the Kennedy Spaceport. Almost 3 million passengers per year take cruise ships from Port Canaveral and a comparable number go to the Kennedy Visitor Center. By transporting passengers to the Port and the Visitor Center, a maglev system would lessen congestion and delays and reduce pollution. The number of people visiting these points is steadily increasing, and will probably double within a decade. The substantial ridership, and the environmental benefits, make this route an excellent candidate for the first US maglev system.